Characterization of three novel monoclonal anti-Oka

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

production and characterization of new anti-human cd20 monoclonal antibody

the b-cell cd20 antigen is one of the most reliable surface targets in immunotherapy of b lymphoma. in this project, we studied the production and characterization of a new monoclonal antibody against chimeric human cd20 extra loops (hcd20 exl). the results showed that clone c12h, igg2/k isotype reacted with the antigen in elisa and immunoblot. the kd value was  found to be 2×10-9m and flow cyt...

production and characterization of anti-her2 monoclonal antibodies

objective: breast cancer is the most common cancer among women in the world. early diagnosis of this cancer is a key element for its treatment. one of the approaches for diagnosis of breast cancer is detection of its tumour-associated markers. hence, her2 has been the main focus of the researches in the field. materials and methods: for diagnosis of her2 overexpression, monoclonal antibodies (m...

Ofatumumab: a novel monoclonal anti-CD20 antibody

Ofatumumab, a novel humanized monoclonal anti-CD20 antibody, was recently approved by the FDA for the treatment of fludarabine and alemtuzumab refractory chronic lymphocytic leukemia (CLL). Ofatumumab effectively induces complement-dependent cytotoxicity (CDC) in vitro, and recent studies demonstrated that ofatumumab also effectively mediates antibody-dependent cellular cytotoxicity (ADCC). Pha...

Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages.

Mouse monoclonal antibodies with varying specificities against the Gag capsid of simian and human immunodeficiency virus (SIV/HIV) were generated by immunizing mice with whole inactivated SIVagmTYO-1. Monoclonal antibody AG3.0 showed the broadest reactivity recognizing the Gag capsid protein (p24-27) and Gag precursors p38, p55, and p150 of HIV-1, HIV-2, SIVmac, and SIVagm. Using overlapping pe...